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Joint and muscle pain Aching in joints (especially fingers, wrists, and knees) and muscles is common, particularly in the first few weeks

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Critically, FOXO4-DRI treatment had no measurable effect on cell viability of non-senescent cells

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Prioritizing protein intake (0.5-0.9g/lb of body weight daily) and spreading consumption throughout the day optimizes muscle protein synthesis

Timing is critical: cramping that begins within days of starting therapy may reflect acute metabolic adjustment, while cramping that emerges weeks later might indicate cumulative electrolyte loss, reduced hydration, or inadequate nutrient intake during weight loss