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NRF2 is regulated through two principal mechanisms: post-translational modifications (PTMs) and epigenetic alterations

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External heat sources such as warm water, heating pads, or direct sunlight should never be used, as elevated temperatures can degrade the peptide and compromise its biological activity

Moreover, deficiency of autophagy regulatory factors such as autophagy-related 4C cysteine peptidase (ATG4C) is more likely to cause cancer (50)

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