2012 Apr 1;35(4):5137
In PIONEER phase 3 clinical trials, Rybelsus reduced glycated hemoglobin levels (HbA1c) by 1.3% after 26 weeks compared to 0.9% with Jardiance
For others, it is Wegovy or Mounjaro
Studies show that Glutathione depletion is one of the earliest changes observed in neurodegenerative conditions such as Parkinsons and Alzheimers disease, where oxidative stress damages dopamine-producing neurons
Curr Med Chem 21(32):36623672 Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID (2006) Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption
The critical point about side effects: they are almost always most pronounced during dose escalation and improve significantly or resolve entirely once a patient reaches a stable maintenance dose