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Manipulation of gut microbiota influences immune responses, axon preservation, and motor disability in a model of progressive multiple sclerosis

343 Evexomostat (SDX-7320), which irreversibly binds METAP2 and regulates insulin, leptin, and adiponectin downstream, was one of the first drugs developed for cancer patients with metabolic complications

Pathway sources, original pathway names, and the names applied here for each pathway macro-category are provided in Supplementary Table S1

46 Activation of lossoffunction MC1R variants has also been shown to activate p38 mitogenactivated protein kinase (MAPK), extracellular signalregulated kinase 1 and 2 (ERK1/2) and Akt pathways

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