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Long R3 IGF-1 is modified to help increase its potency and stability while still exerting anabolic effects similar to IGF-1 Long stands for the additional 13 amino acids added to the N-terminus of the peptide molecule, while R3 describes the replacement of the 3rd amino acid in the native hormone with arginine

For autophagic flux determination, cells were viewed under a laser confocal microscope (LSM 510

Trends Endocrinol Metab 28(11):794806 Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F et al (2014) The IRE1alpha-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic beta-cells

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