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In REDEFINE 2, which included participants with type 2 diabetes (a population that typically shows lower weight loss with any intervention), CagriSema achieved 13.7% weight loss compared to 3.4% with placebo

Taspoglutide (a long acting GLP-1 agonist) was not found to have significant anti-atheromatous effects, although it did reduce hepatic triglyceride levels, suggesting an indirect mode of action [97]

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