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The FDA classified it as Category 2 (no compounding allowed) due to lack of safety data

Acute phase (weeks 08): If Lyme disease is detected in this phase with early symptoms, the treatment process targets the active infection

Given that age and sex ratio were unevenly distributed between the ASD and HC groups and the HC subjects were from different sources (local community, kindergarten/primary school and clinical center) in some included studies (eTable 1), we performed the stratified analyses based on the three factors

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Corrective measures should be taken if the cause is preventable or reversible