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doi: 10.1111/j.1365-2036.2007.03346.x

PMID 34959912

Because of the potential risks of high-dose magnesium supplementation, especially in those with impaired kidney function, supplementation with magnesium should be conducted under medical supervision

This combination has not been studied in clinical trials, so any such approach would be highly experimental

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According to a study by Obeid et al., a widely accepted expert consensus on diagnosing and treating vitamin B12 deficiency, recognized that untreated deficiency can lead to irreversible symptoms