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Developing a system to remember when to take it each week may also help reduce the risk of errors in dosing. While most patients who had GLP-1 RA overdose reported no symptoms, gastrointestinal symptoms such as nausea, vomiting, generalized weakness and abdominal pain are some of the most common when symptoms occur

Starting at 50 units would deliver 1.0 to 2.5 mg depending on concentration, which is far above the recommended starting level and would likely cause severe nausea and vomiting

A year later Bloom's group published a study which demonstrated that rats completely lost interest in food when GLP- 1 (7-36) was injected directly into the hypothalamus part of their brains

Okabe K, Matsushima S, Ikeda S, Ikeda M, Ishikita A, Tadokoro T, Enzan N, Yamamoto T, Sada M, Deguchi H

This peptide mimics the effects of glucagon-like peptide-1 (GLP-1), a hormone responsible for regulating hunger and glucose metabolism

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