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It has been postulated that the rapid reduction in blood glucose levels triggered by GLP-1 RAs leads to a hypoxic state of the retina that promotes further abnormal angiogenesis, Reut Shor , MD , of the department of ophthalmology and vision sciences at the University of Toronto, and colleagues wrote

The 24 hour secretory pattern of plasma PRL levels is disrupted and reduced in high fat diet(HFD) rats (56) counteracts the insulin resistance and adipose tissue dysfunction (57)

doi: 10.3390/microorganisms8060830 106 VaqueroC.LoiraI.HerasJ

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