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The Ministry of Health, Labour and Welfare and the PMDA have issued warnings regarding this as a serious side effect of GLP-1 receptor agonists

In a diabetic retinopathy model, AST treatment elevated the levels of the antioxidant enzyme heme oxygenase-1 (HO-1) and preserved homeostasis for retinal ganglion cells (Yoshihisa et al., 2014)

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