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J Neuroendocrinol 2010

Unlike fat-soluble vitamins that accumulate in body tissues, water-soluble vitamins dissolve in water and are typically excreted through urine

The docked flavonoids were also noted for additional substantial intermolecular interactions with the hydrophobic and aromatic residues around the catalytic site of mh-Tyr structure

Structural basis of Keap1 interactions with Nrf2

The implications of this finding are profound

Even though we knew for a long time that dysregulated insulin production was one of the causes of diabetes, especially, obviously Type 1 and Type 2 diabetes, we didn't know exactly why there was this dysregulation, so the GLP discovery helped us understand more about how insulin is created in the body