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They include - Nausea (the most common one across both) Constipation Diarrhoea Fatigue, particularly in early weeks Unique side effects to the pill - In OASIS 4, vomiting was notably more common with the pill than typically reported with the injection: Nausea: 46.6% (pill) vs 18.6% (placebo) in OASIS 4 Vomiting: 30.9% (pill) vs 5.9% (placebo) - higher than usually seen with the needle version Discontinuation due to adverse events: 6.9% with the pill, similar to the injection Fasting could be the main reason behind the higher vomiting rates

Mutations in tumor suppressor genes 1 and 2 (BRCA1 and BRCA2), which are involved in repairing damaged DNA, are among the genetic factors studied

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In patients vaccinated against herpes zoster, GLP-1RA use did not significantly increase the risk of composite outcomes, herpes simplex, or herpes zoster infections compared with DPP-4i or SGLT-2i use (Table 3)

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Not specific to IGF-1 LR3 but pathway-relevant