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Fusion of the mouse IgG1 Fc domain to the VHH fragment (ARP1) enhances protection in a mouse model of rotavirus

Hit validation by transverse relaxation rate (R2) analysis To further characterise the two site-specific hits from the NMR fragment screen, we measured the transverse relaxation rate of the fragments with and without TRF1 TRFH

Experts dont know the exact cause of vasomotor symptoms (hot flashes and night sweats)

A heart expert can run tests to rule out any underlying problems

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The cagrilintide dosing protocols are still being established, but the mechanism of action, targeting amylin receptors for appetite regulation, offers a novel pathway distinct from GLP-1 agonism