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Released in a diurnal pattern with peak levels in early morning, cortisol influences carbohydrate, protein, and lipid metabolism through multiple mechanisms

Yusuf S, Joseph P, Rangarajan S, Islam S, Mente A, Hystad P, et al

Methods: We did a 40-week, randomised, active-controlled, parallel-group, double-blind, phase 3B trial (SUSTAIN FORTE) at 125 outpatient clinics in ten countries

Injection formulations deliver 100% of the dose directly into the bloodstream, matching the clinical trial evidence showing 22% average weight loss

Niciu et al

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