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Some topical products like hydroquinone or azelaic acid can slow down melanin production, but not as effectively or profoundly as oral tranexamic acid. And oral is the key word here: Though tranexamic acid can be used topically to slow melanin synthesis, clinical studies show it works much more effectively when taken in pill-form

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Five clinical trials met the inclusion criteria

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The oxidative stress is the result of the imbalance of the antioxidant system in favor of prooxidants, which interferes with the GSH/GSSG system in the antioxidant defense and the regulation of gene expression, the synthesis of DNA and proteins, cell proliferation and apoptosis, and cytokine production and protein glutathionylation, due to alteration of certain cellular functions

The digestive tract is a harsh environment designed to break things down