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In late 2024, Zealand Pharma initiated a phase 2b randomized dose-finding obesity and T2DM + obesity clinical trial (ZUPREME-1 and ZUPREME-2) which will evaluate petrelintides efficacy and safety in individuals with obesity in a larger population ( N = 480) [116]

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This timing recommendation is based on the medication's short-acting profile and its mechanism of slowing gastric emptying, which is most beneficial when timed with food intake

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