38 In one controlled clinical trial, 70 patients with sudden unexplained sensorineural hearing loss were treated with 7,800 mcg RAE (26,000 IU) beta-carotene (pro-vitamin A), 200 mg vitamin C, 90 mg (200 IU) vitamin E (d-alpha tocopherol), and 50 mcg of the mineral selenium twice daily as an adjunct to medical therapy as well as hyperbaric oxygen, while 56 similar patients received medical and hyperbaric oxygen therapies alone, for 30 days
Bhattacharjee AK, Chang L, White L, Bazinet RP, Rapoport SI
Evens out complexion, and combats signs of premature ageing and dullness
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The lack of FDA approval for human use and the need for higher doses in some experimental settings underscore the importance of evaluating safety and efficacy under strict medical supervision
Similar mechanisms in which the GSH-thiolate acts as a Brnsted base catalyst have been suggested for the well-studied isomerization of ketosteroids by GST A3-3 43 (Extended Data Fig