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All treatments, including the control, were given using stomach tube gavage once daily for consecutive 56 days (8 weeks) to cover one complete spermatogenic cycle of the rat

Methylglyoxal evokes pain by stimulating TRPA1

Tobacco use, an irritating lip product, chronic sun exposure without protection: these are ongoing stimuli

similarly, it was reported that ob/ob mice (Garca-Ruiz and Fernndez-Checa 2018) as well as mice fed a high-fructose diet (Li and Lu 2018) exhibited a decrease in the GPx activity as compared to controls, respectively

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M.AxelmanK.ForsellC.et al (2001)