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Published in Nature Communications , the study provides the first randomized, placebo-controlled evidence in humans that semaglutide may slow the buildup of DNA markers linked to biological aging in adults living with HIV

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In contrast, recent meta-analyses that included large-scale cardiovascular outcome trials (CVOTs) suggest that GLP-1 RAs do not significantly increase the risk of acute pancreatitis or pancreatic cancer in patients with T2DM (Cao, et al., 2020)

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This distinction is critical, as even a biologically promising compound may become clinically harmful when delivered through nonstandardized formulations

Continue increasing by 0.25 to 0.5 mg every 4 weeks until reaching the target dose or maximum tolerated dose