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Intriguingly, the R groups exhibited a significant elevation in the plasma ATP compared to the HC and R groups ( Figure 6M )

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As a result of overexpression GGCT, not only did the level of glutamate m + 5 decrease, but also the levels of downstream metabolites such as -KG m + 5, succinate m + 4, fumarate m + 4 and malate m + 4 in the TCA cycle were affected (Fig