developed tissue specific KOs of HSL in adipocytes and liver
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They found that the oligomers (but not monomers) had detrimental metabolic effects and caused pro-arrhythmic electrophysiological changes in atrial cells and hypertensive mice
In particular, GSH catalytically detoxifies from hydroperoxides, peroxynitrite, and lipid peroxides and directly scavenges various oxidant molecules, like superoxide anion, hydroxyl radical, nitric oxide, and carbon radicals
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