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This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption

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Consequently, there is an urgent need for innovative chemical structures and strategies to bolster the stability of bioactive peptides, while the production is convenient and cost-effective

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doi: 10.1016/j.mtbio.2025.101621 126 QuQ.YangF.ZhaoC.LiuX.YangP.LiZ.et al

This cascade of effects ultimately results in lower overall sulfite levels, despite riboflavins role in the initial conversion of H2S to sulfite