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However, some studies suggest that these side effects may be slightly more common or intense with tirzepatide, likely due to its dual-agonist action and higher efficacy

Diabetes Care 26 , 31603167 (2003)

Considered simplistically, four enzymes are involved in the cycle of -oxidation of a long-chain saturated fatty acid as its CoA ester in mitochondria

Diabetes Care 43(Supplement 1):S98

Source: Manterola et al.5 Worldwide, the accumulated incidence of HE in cirrhotic patients at 1, 5, and 10 years varies from 0 to 21%, 5 to 25%, and 7 to 42%, respectively

Some people continue to lose weight smoothly even after switching medications, while others may notice a slower pace at first or regain some of the weight they have lost