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Furthermore, evidence points toward exposure between birth and approximately 5 years of age as the period of highest risk, with the risk during prenatal exposure being significant in numerous studies [4] albeit less consequential [2,3]

doi: 10.1177/15648265080292S103

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This included Israel Simon Kleiner and Samuel Meltzer, two American physiologists, based at the Rockefeller University in New York who in 1915 demonstrated with animal experiments the power of intravenously administered pancreatic extracts in lowering blood sugar