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1 Introduction Diabetes mellitus is a metabolic disease characterised by insulin resistance and pancreatic -cell dysfunction leading to disorders in glucose glucose metabolism, which can lead to chronic complications in the body such as cardiovascular disease, nephropathy, retinopathy and others (1)

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Activates AMPK (The Metabolic Master Switch) MOTS-C activates AMP-activated protein kinase (AMPK) often called the metabolic master switch. AMPK activation: Increases glucose uptake into cells (improving insulin sensitivity) Enhances fat oxidation (fat burning) Increases mitochondrial biogenesis (creating new, healthy mitochondria) Reduces inflammation Promotes autophagy (cellular cleanup and renewal) This is the same pathway activated by exercise and calorie restriction two of the most powerful interventions for metabolic health and longevity

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