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T., & McIntyre, R

Pfeffer MA, Claggett B, Assmann SF, et al

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The stomach's intrinsic factor-producing cells are attacked and destroyed by the autoimmune disorder, which results in a vitamin B12 deficiency

As MC4R deficiency presents with severe obesity from childhood, trials of tirzepatide (NCT06439277 and NCT06075667) and other obesity medications in children and adolescents with obesity, including those with MC4R deficiency, are needed to provide the evidence base for earlier, and potentially chronic, treatment in genetically driven obesity

PPAR ligands are potent inducers of apoptosis in leukemias and lymphomas