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Recently, administration of the AdipoR agonist AdipoRon was found to effectively reduce the levels of the pro-inflammatory factor tumor necrosis factor (TNF-) and mitigate disc degeneration ( 2.3 Progranulin PGRN, a secreted glycoprotein that can be cleaved into granulins by enzymes like elastase, exerts anti-inflammatory effects and plays protective roles by enhancing cell proliferation and through interacting with TNF receptors (TNFRs) or other receptors