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Slower dose titration may help reduce nausea and vomiting, thereby limiting electrolyte losses

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observed two distinct populations of alpha-cells with similar proglucagon expression but differential expression of proliferation-associated genes (e.g., TOP2A , MKI67 , CENPF , BIRC5 , and CDK1 ), suggesting that one of these subpopulations, albeit the smaller subpopulation, of alpha-cells may constitute proliferating alpha-cells (71)