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2 , 59 , 60 , 61 These DNA changes almost all are missense mutations leading to single amino acid substitutions in the enzyme

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ClinicalTrials.gov trial NCT04892136 (2022 interim) supported scalp perfusion improvements clinicaltrials.gov

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If side effects are troublesome, patients may need to extend time at their current dose, step back to a previously tolerated dose, or temporarily pause treatment before re-escalating, always under clinician guidance