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During pregnancy, factors that contribute to oxidative stress include: Hormonal Changes : Elevated hormone levels can increase metabolic activity, leading to more ROS production

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For example, luteolin, a plant-derived flavonoid, downregulates the proinflammatory cytokines in macrophages and inhibits the production of nitric oxide and pro-inflammatory arachidonic acid by blocking the nuclear factor B (NF-B) signaling pathway (174)

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