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Baseline assessment should include current thyroid status with TSH, free T4, and free T3 levels, documentation of Graves disease treatment history and current management, assessment of thyroid eye disease or other complications, cardiovascular evaluation including heart rate and rhythm (as both hyperthyroidism and GLP-1 receptor agonists can affect heart rate), and standard metabolic parameters including HbA1c, lipid profile, and renal function

Many major insurance plans now cover semaglutide for weight loss when prescribed for patients who meet medical criteria

As a result, many patients eat less, experience fewer cravings, and find it easier to maintain a calorie deficit

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These distinctions are critical for experimental interpretation

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