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However, by increasing SIRT1 accumulation in the ovary, SP and L-car could attenuate DOX-induced mtDNA damage in ovarian cells, subsequent mitochondrial dysfunction, and resulting apoptosis in preantral follicles, which was consistent with the earlier observation 92

The present study also indicated that dietary L-carnitine supplementation downregulated significantly the expression of adipogenesis-related genes, such as ACC, FAS and DGAT

Normington, K