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In colorectal cancer cell lines (HT-29 and SW620), knockdown of IGF-1R by small interfering RNA resulted in a blockade of the downstream PI3K/Akt and typical Wnt signaling pathways, which ultimately inhibited cancer cell proliferation and promoted apoptosis (103)

Jossy Onwude, MDJul 1, 202613 min read Hormones & Metabolism Measuring Peptide Therapy Success: 12 Biomarkers That Matter More Than the Scale Learn which peptide therapy biomarkers actually measure success from IGF-1 and HOMA-IR to testosterone and liver enzymes