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For those with healthy DAO levels, nearly all the histamine derived from food sources are broken down by their DAO enzymes

Nevertheless, studies utilizing more specific biomarkers of vitamin B 12 status, including measures of holo-transcobalamin and methylmalonic acid, have shown more consistent results and a trend towards associations between poor vitamin B 12 status and faster cognitive decline and increased risk of Alzheimers disease (82-86)

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JS Cohn et al

Everyone bangs on about skin when it comes to this, but I get excited because it up regulates PGC 1 alpha, which stimulates mitochondrial biogenesis