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doi:10.1177/0091270005278806 150

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definitely in the last several years

The CONQUER study enrolled 2,487 overweight and obese adults, with participants receiving high-dose Qsymia (15mg phentermine/92mg topiramate) achieving 10.2% weight loss compared to 1.8% with placebo

3 GLP-1 Receptor Agonists (GLP-1RAs) in the Central Nervous System and the Energy Balance in Rodents GLP-1 is synthesized in NTS neurons that project to GLP-1R-expressing regions, such as the paraventricular nucleus (PVN) and ARC [23]