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The Catch: Sesame's model is highly fragmented

Particularly semaglutide and tirzepatide

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They were developed using structural modifications such as acylation with a fatty acid chain to facilitate albumin binding increasing its half-life to 13h after a single injection with Liraglutide, and then further refined to an increased human plasma half-life of 160h for Semaglutide which is also protected from dipeptidyl peptidase-4 cleavage

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Toxicity and hepatocarcinogenicity may occur when liver responses exceed adaptive changes or induced enzymes generate toxic metabolites