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The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta-analysis

These drugs are also prescribed to diabetes patients with obesity and cardiovascular conditions

Leung, Y

GLP-1 helps regulate blood sugar levels by stimulating the release of insulin, suppressing glucagon secretion (which raises blood sugar levels), and slowing the rate at which the stomach empties, leading to a feeling of fullness and reduced appetite

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The early deterioration of diabetic retinopathy observed with GLP-1 RAs may reflect rapid glucose decline that affects osmotic pressure rather than direct retinal toxicity [91]