have anti-inflammatory, anti-ischemic and anti-fibrotic effects and inhibit myocardiocyte apoptosis.29,32,42 More recently, it has been reported that they also reduce epicardial fat.43 They also inhibit platelet aggregation and thrombosis.44 In the lungs, rGLP-1 activation conferred protection against lipopolysaccharide-induced acute lung injury.45 In adipose tissue they favor adipocyte differentiation, decreases lipid deposition in white fat and facilitate its conversion to brown fat, as well as thermogenesis and energy consumption29,32,4648
2019;7:e14139
Allow the area to dry completely before proceeding
New England Journal of Medicine, 2023
The glucagon component may partially offset constipation through its own gastrointestinal effects, but published data is still limited
When one-third of participants were randomized to take a placebo instead of semaglutide for 48 months, they regained 7 percent of the weight they lost