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"Other side effects are possible, such as headaches or injection site reactions, since most GLP-1 agonists are taken as an injection," comments Mitri
In a randomized, double-blind, placebo-controlled trial in 2,919 participants (65 years) with elevated blood concentrations of homocysteine, supplementation with vitamin B 12 (500 g/day) and folic acid (400 g/day) for two years did not decrease the risk of osteoporotic fracture despite reductions in homocysteine (120, 121)
This is especially meaningful for chronic kidney disease, where inflammation, immune dysfunction, and tissue damage drive long-term decline
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