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Among patients with lymphoma, eight complete response (CR) and one PR were observed, with a 2-year PFS rate of 63%

The peptide segment LKKTETQ, which is the active ingredient in TB-500, is responsible for actin binding, cell migration, and wound healing

Rubio JC., et al

However, gastrointestinal toxicity was still prominent and clinical outcomes were not satisfying due to its low tolerability

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Drug development continues to face marked inefficiencies, with approximately 90% of drug candidates failing to reach approval despite extensive preclinical testing ( in vitro models, although cost-effective and suitable for high-throughput studies, lack the architectural complexity and biochemical microenvironment of human tissues