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N Engl J Med 364(6):501513 Motzer RJ et al (2009) Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma

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Such disturbance occurred through decreasing the transcription of thyroid hormone receptors (TR) by disrupting the physiological concentrations of thyroid hormones, thereby increasing the ligand-dependent cooperativity of TR with the co-repressors and shedding of the co-activator

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Fortunately, clinical studies in men have not reported serious cardiac events attributable to bremelanotide, and the injection formulations BP effect is much less pronounced than the old intranasal version