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JCI Insight 5(6):e133429 Drucker DJ (2018) Mechanisms of action and therapeutic application of glucagon-like peptide-1

Higher-dose GLP-1 medications used for weight loss are typically meant to correct a metabolic problem , not necessarily be a lifelong high-dose solution

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Together, these pathways make Retatrutide a useful model compound for research into multi-receptor metabolic signalling rather than single-pathway incretin activity alone

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These were reflected in improvements in lipid profiles and glycemic control, with notable reductions in HbA1c and insulin requirements, although the magnitude of benefit varied by specific GLP-1 RA, dosage, and duration of follow-up