In some cases, massive hepatic necrosis leads to fulminant hepatic failure with complications of bleeding, hypoglycemia, renal failure, hepatic encephalopathy, cerebral edema, sepsis, multiple organ failure, and death within days
Lever 2005
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Thirteen patients (56.5%) were activated on the transplant waiting list in a median time of 5.4 months and 61.5% of them (8/13) were further transplanted in a median time of 3.9 months
In addition, PEGylation reduces the clearance of protein drugs by reticuloendothelial tissue, shields antigenic determinants, reduces immune system recognition, and prevents degradation by proteolytic enzymes
COA for every lot produced.