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This enabled us to characterise genetic changes associated with progressive disease, finding that tetraploidization and acquisition of aneuploidy are dominant mutational mechanisms across evolution to end-stage, fatal melanoma

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Plant SULTRs are evolutionary related to the SLC26 group, but with a reaction mechanism of H + /sulfate symport, similar to the SLC13 group, which use Na + (Takahashi et al., 2011a)

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