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Under conditions of severe oxidative or genotoxic stress, p53 promotes transcription of pro-apoptotic genes such as Bax and PUMA, thereby facilitating mitochondrial outer membrane permeabilization and apoptosis ( NRF2 is a master regulator of antioxidant and cytoprotective gene expression that responds to alterations in mitochondrial redox state

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Numerous S -nitrosylated proteins such as Bcl-2, p53, HIF-1, PTEN, and Src are involved in cell survival, angiogenesis, tumorigenesis, and response to cancer treatment (6368)