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We report two female patients with long-standing CSU who experienced rapid and sustained remission after initiation of GLP-1RA therapy (semaglutide or tirzepatide), prescribed primarily for metabolic indications

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10.1038/75068 6 BojarskaJ

They discuss why native GLP-1 is too short-lived to be therapeutic and outline engineering strategies that extend half-life (e.g., fatty-acid albumin binding or Fc-fusion), walking through approved agents like exenatide, liraglutide, dulaglutide, lixisenatide, semaglutide, and tirzepatide (a dual GIP/GLP-1 agonist)