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These medications mimic the action of naturally occurring GLP-1, an incretin hormone produced in the intestines in response to food intake

Arakawa M, Mita T, Azuma K, Ebato C, Goto H, Nomiyama T, Fujitani Y, Hirose T, Kawamori R, Watada H: Inhibition of monocyte adhesion to endothelial cells and attenuation of atherosclerotic lesion by a glucagon-like peptide-1 receptor agonist, exendin-4

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The critical point: adding more peptides to a protocol does not change how you calculate retatrutide doses