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In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein (CRP) in adults with high levels of CRP (29)

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Notably, tirzepatide is a dual incretin receptor agonist that activates both the glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor, distinguishing it from other GLP-1-specific agonists

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Results of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, which compared dapagliflozin (10 mg once daily) to placebo, found that dapagliflozin was associated with a 44% reduction in a composite of adverse kidney outcomes and a 29% reduction in death from cardiovascular causes or hospitalization for heart failure