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Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Furthermore, this study goes beyond computational analysis by integrating in vitro experiments (CCK8, EdU, flow cytometry, and qPCR), systematically validating the effects of oxidative stress on the expression of key cataract genes (DKK3 and GSTM1) and the biological behavior of lens epithelial cells, thereby enhancing the biological credibility and translational significance of the findings

In addition, FSP1 and GCH1, two other markers of ferroptosis [19, 20], are also transcriptionally upregulated during acute disease, possibly counteracting the loss of GPX4 (Fig